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LRIG Philadelphia 8th Virtual Scientific Meeting

posted Jul 3, 2021, 8:56 AM by Rodney Bednar   [ updated Aug 6, 2021, 8:30 AM by Jackson Hyde ]


On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.  


For Direct Video Link:  https://youtu.be/r6KpFJqieTY




The 8th Virtual Scientific Meeting is Wednesday, July 7th @ NOON! 
 


Please encourage your friends and colleagues to register now for this exciting talk.


Register Now on Eventbrite

LRIG-Philadelphia's Virtual Scientific Meetings provide an opportunity for Scientists to share their research with the LRIG Community.

Join us Wednesday, July 7th @ NOON!  Spend your lunchtime with us learning about the scientific application of mixed reality technology from Elliot Drake, Mixed Reality Digital Technology Specialist at GlaxoSmithKline in Collegeville, PA. 

Free Registration Here

 

Overview of Presentation:

Applications of Mixed Reality Technology for Remote Collaboration and Scientific Training

Due to new-found remote working requirements and social distancing guidelines, GSK has been required to innovate on how it proceeds with global business practices. In this presentation, we will discuss several of the new digital technologies we used to overcome these challenges, and the use cases involved.

 


   LRIG-Philadelphia Virtual Scientific Meeting July 2021 image

Elliot Drake

Elliot Drake is a Mixed Reality Digital Technology Specialist at GlaxoSmithKline in Collegeville, PA. As part of the Analytical Platforms and Platform Modernization group, he and his team support initiatives within the GSK portfolio that focus on digital technology, systems innovation, & business intelligence. His work involves the utilization of Smartglasses, Augmented workflows, Paperless data capture, and AR/VR training modules.

Elliot has direct experience in the fields of Human Computer Interaction, Imaging & 3-D Visualization, Computer graphics, Wearable Technology, Graphical User Interfaces, Internet of Things, and Mixed Reality Training.

LinkedIn: https://linkedin.com/in/ElliotHDrake

Title: Applications of Mixed Reality Technology for Remote Collaboration and Scientific Training

Elliot Drake , GlaxoSmithKline, Collegeville, PA

Abstract: Our first use case involves using Smartglasses technology for an “I See What You See” method that allows users to troubleshoot, train, method-transfer, and audit remotely between sites and both internal and external users. The use of Smartglasses can reduce travel frequencies to different internal sites and external CROs, especially during Covid-19, to troubleshoot and work as a training aid through streaming and video recording, which promotes effective and efficient decision making to meet project timelines.

The second use case involves a direct collaboration with our Vaccines group. Using a group of Virtual Reality training modules to assist with the training of new scientists on following safe procedures when working with HPLC & Lab automation instruments. This is completed with a combination of pre-built and bespoke virtual training modules.

Once the various applications are set up, they reduce time required for traveling or on-site business needs for scientists across different business units. Saving time, resources, capital, and focusing on keeping our scientists safe.

Click Here For Tickets

Help spread the word out about this new forum for Scientists to share their Research and Innovations with the entire LRIG community.   All Laboratory Research and Innovation Group of Philadelphia (LRIG-Philadelphia) events are free and open to all.

If you are interested in presenting or organizing a future event, please send your proposal to Talks.PHL@lrig.org.

Thank you, we'll "see you" on July 7th

Register Now

LRIG Philadelphia 7th Virtual Scientific Meeting

posted Apr 15, 2021, 8:38 AM by Rodney Bednar   [ updated Jul 3, 2021, 9:04 AM ]


https://www.youtube.com/channel/UCI4hxTqKyOwpCnGCxMRulWA

On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.  






For Direct Video Link:


1st Presentation: "Advances in Sonication for MultiOmics Applications with PIXUL" 

Direct Video Link is: https://youtu.be/8Adz_LYaMM8 


2nd Presentation: "Nanoliter Droplet Dispensers for Analytical Mass Spectrometry and other Applications" 

Direct Video Link is: https://youtu.be/otF9GuOr8Yg  




The 7th Virtual Scientific Meeting is Wednesday, May 5th @ NOON!  

Please encourage your friends and colleagues to register now for this exciting talk.

Register Now on Eventbrite

LRIG Philadelphia 6th Virtual Scientific Meeting

posted Apr 3, 2021, 9:08 AM by Rodney Bednar   [ updated Apr 20, 2021, 7:34 PM ]


On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.  


For Direct Video Link:  https://youtu.be/0J2m6RfwDxU





The 6th Virtual Scientific Meeting is Wednesday, April 7th @ NOON!  

Please encourage your friends and colleagues to register now for this exciting talk.

Register Now on Eventbrite


The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) is proud to announce our next Virtual Scientific Meeting. This virtual forum provides an opportunity for Scientists to share their Research & Innovations with the entire LRIG Community.  This ongoing series is free to attend and open to all.

About this Event

This lunchtime "WebEx" event will feature Dual Presentations on High Throughput Cellular Thermal Shift by Scientists at NIH/NCATS and at GSK. There will also be an opportunity for questions and answers.

Overview of Presentations:

High Throughput Cellular Thermal Shift Assays (CETSA): Approaches and Applications

During this webinar, high-throughput cellular thermal shift assays (CETSA) will be discussed. CETSA can be used as a method to detect the engagement of a small molecule with a protein target in cells. High throughput methods and applications will be presented.

Please remember to register and join us for this exciting virtual event. The evening before the event you will receive a link that will allow you to join the WebEx meeting.

See below for information on our speakers and an abstract of their presentations.


   LRIG-Philadelphia Virtual Scientific Meeting April 2021 image

Mark Henderson

Dr. Mark Henderson is a Biology Group Leader in the Early Translation Branch at the National Center for Advancing Translational Sciences (NCATS). His team works on collaborative projects aiming to identify small molecules for disease-relevant targets, focusing on cellular processes that are dysregulated across multiple disorders. He has experience in the design, development, and implementation of high throughput screening assays.

LinkedIn: https://www.linkedin.com/in/mark-j-henderson/


   LRIG-Philadelphia Virtual Scientific Meeting April 2021 image

Lorena Kallal, PhD

Lorena Kallal is a scientist and manager at GlaxoSmithKline in Collegeville, PA. As part of the Screening, Profiling and Mechanistic Biology Department, her team supports programs across the GSK portfolio with cellular assays and experimentation. Lorena has expertise in high throughput screening, phenotypic assays, and drug discovery strategy.

LinkedIn: http://www.linkedin.com/in/lorena-kallal-7389a672

Title: High throughput cellular thermal shift assays (CETSA): approaches and applications.

Mark Henderson, National Center for Advancing Translational Sciences (NCATS), NIH & Lorena Kallal , GlaxoSmithKline, Collegeville, PA

Abstract : The cellular thermal shift assay (CETSA) is a valuable method to assess target engagement within the cellular environment by measuring changes in thermal stability of a protein conferred by ligand binding. The traditional CETSA method is labor intensive, which limits its use when testing large sets of compounds during screening or lead optimization. In recent years, several high-throughput CETSA approaches have been developed to overcome this limitation. During this webinar, we will describe high-throughput CETSA approaches and discuss strengths, pitfalls, and potential applications of these technologies.


Register Now on Eventbrite

 

Help spread the word out about this new forum for Scientists to share their Research and Innovations with the entire LRIG community.   All Laboratory Research and Innovation Group of Philadelphia (LRIG-Philadelphia) events are free and open to all.

If you are interested in presenting or organizing a future event, please send your proposal to Talks.PHL@lrig.org.

Thank you, we'll "see you" on April 7th

Register Now on Eventbrite

LRIG Philadelphia 5th Virtual Scientific Meeting

posted Mar 5, 2021, 11:48 AM by Rodney Bednar   [ updated Mar 5, 2021, 11:50 AM ]

https://youtu.be/aB6IAD743L8
On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.  See: 
https://youtu.be/aB6IAD743L8






The 5th Virtual Scientific Meeting is on Wednesday, March 3rd, 2021 @ NOON! 

Please encourage your friends and colleagues to register now for this exciting talk.

REGISTER NOW!


The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) is proud to announce our next Virtual Scientific Meeting. This virtual forum provides an opportunity for Scientists to share their Research & Innovations with the entire LRIG Community.  This ongoing series is free to attend and open to all.

About this Event:

   LRIG-Philadelphia Virtual Scientific Meeting March 2021 image

The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) and The Pennsylvania Drug Discovery Institute (http://www.padrugdiscovery.org/) is proud to present another Virtual Scientific Meeting. This lunchtime "WebEx" event will feature a presentation by President & CEO of Melior Pharmaceuticals and an opportunity for questions and answers.

Overview of Presentation:

Harnessing Pharmacological Pleiotropy for Drug Repositioning

Although the word “pleiotropy” is customarily used in a genetic sense to refer to the phenomenon where a gene effects multiple traits, here we take the liberty to use it in the sense of a drug having multiple therapeutic actions. We use the biology of lyn kinase, and the activator of lyn kinase, MLR-1023, as an illustrative example.

Please remember to register and join us for this exciting virtual event. The evening before the event you will receive a link that will allow you to join the WebEx meeting.

See below for Information on our speaker and an abstract of his presentation.


   LRIG-Philadelphia Virtual Scientific Meeting March 2021 image

Andrew Reaume

Dr. Reaume is President, CEO and co-founder of Melior Discovery, Inc., an established biopharmaceutical company dedicated to in vivo phenotypic screening and drug repositioning. Under Dr. Reaume’s leadership the Company has advanced from a discovery stage R&D operation to a clinical stage company having completed 2 successful Phase 2 studies involving more than 80 clinical sites across 2 countries. Dr. Reaume has provided instrumental contribution to many key elements of the company’s progress including investment financing, partnership activity for the company’s services, business model architecture and out-licensing of the company’s lead product.

Prior to starting Melior, Dr. Reaume was a Senior Business Analyst at Pfizer Global Research and Development Inc. where, among other activities, he spearheaded a major genomics technology initiative involving impacting all therapeutic areas and involving collaboration with stakeholders throughout the Pfizer global organization. Before Pfizer. he was a Research Scientist in R&D at Cephalon, Inc. where, in addition to R&D activities he became involved in identifying and coordinating in-licensing opportunities. He received his MBA from the Wharton School where he graduated with honors in Entrepreneurial Management. He received his PhD in genetics from the University of Connecticut.

LinkedIn: https://www.linkedin.com/in/andrew-reaume-38b1a72/

Title: Harnessing Pharmacological Pleiotropy for Drug Repositioning

Abstract : Study of the pharmaceutical discovery process, its evolution over the last three or four decades, and its persistent high attrition rate, make it clear that scientific progress has made little or no inroads towards improving new therapeutic entity discovery. A core tenet of this phenomenon is that there is much more that we do not understand about biological systems than the amount that we do understand. We propose that an element of this lack of understanding is the degree to which the therapeutic targets that are modulated by drugs that we work with are involved in more biology, and thereby more therapeutic potential, than most investigators appreciate. This is reflected in the high rate at which drugs are used for indications other than the ones for which they were originally developed. We have coined this phenomenon of multi-therapeutic application for a single drug, pharmacological pleiotropy. MLR-1023, with its activation of lyn kinase, provides an excellent illustration of pharmacological pleiotropy, detailed with scientific understanding across diverse therapeutic space, animal model validation in every case, and with at least two instances of clinical validation. The story also serves as a good example of the fact that there is much more to successful drug discovery and development beyond accomplishing the already arduous take of clinically proving that a drug is safe, well-tolerated and effective for the pursued indication. Differentiation from existing therapeutics and robust market exclusivity are equally as vital for a program’s success.


   LRIG-Philadelphia Virtual Scientific Meeting March 2021 image

The Pennsylvania Drug Discovery Institute (PDDI) was founded at the Pennsylvania Biotechnology Center of Bucks County in Doylestown, PA in June 2010 by Dr. Allen Reitz and Kathy Czupich as a 501(c) (3) non-profit organization. The current CEO is Dr. Dennis M. Gross.

Its mission is to provide service to the scientific community with workforce reentry assistance for displaced researchers in the pharmaceutical industry, networking activities and supporting and promoting entrepreneurship. In addition, the PDDI has entered into new initiatives in the area of entrepreneurship education and business development engaging the local business and education community.

Help spread the word out about this new forum for Scientists to share their Research and Innovations with the entire LRIG community.   All Laboratory Research and Innovation Group of Philadelphia (LRIG-Philadelphia) events are free and open to all.

If you are interested in presenting or organizing a future event, please send your proposal to Talks.PHL@lrig.org.

Thank you, we'll "see you" on March 3rd

Register Now! on eventbrite.

LRIG Philadelphia 4th Virtual Scientific Meeting

posted Jan 21, 2021, 2:58 PM by Rodney Bednar   [ updated Feb 26, 2021, 12:37 PM ]


https://www.youtube.com/watch?v=H2dGmvLttOY&t=37s


On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.  See: https://www.youtube.com/watch?v=H2dGmvLttOY&t=37s




The 4th Virtual Scientific Meeting is on Wednesday, February 17th, 2021 @ NOON! 

Please encourage your friends and colleagues to register now for this exciting talk.

The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) is proud to announce our next Virtual Scientific Meeting. This virtual forum provides an opportunity for Scientists to share their Research & Innovations with the entire LRIG Community.  This ongoing series is free to attend and open to all.

We are excited to hear from Dr. Gyuseok L. Kim from the University of Pennsylvania Singh Center for Nanotechnology on Wednesday, February 17th  at noon EST. 


Further details and required registration is on Eventbritehttps://www.eventbrite.com/e/lrig-philadelphia-virtual-scientific-meeting-feb-2021-tickets-137795938361

About this Event

Nanotechnology and Nanofabrication for Biological Applications

Overview of Presentation:

Principle and examples of key nanofabrication techniques, tool capabilities at the Singh center for nanotechnology at Penn will be presented. Then, microfluidic devices and their concepts and process flow will be introduced to understand the nanofabrication for biological applications.

See below for Information on our speaker and an abstract of her presentation.


Gyuseok L. Kim

Dr. Gyuseok L. Kim is a principal scientist at the Singh Center for Nanotechnology at the University of Pennsylvania. He manages the graduate student fellow program that provides masters students with hands-on processing nanofabrication experience. He also runs educational programs such as Engineering Summer Academy at Penn - Nanofabrication course for high school students. Prior to joining Singh Center, he worked at Samsung Electro-Mechanics as a senior engineer, developed the touch screen panel and characterized devices and materials with electron microscopy. He also worked at Helmholtz-Zentrum Geesthacht in Germany as a research assistant. He received the Ph.D. from Grenoble INP in France, BS and MS both in Material Science and Engineering from Seoul National University in South Korea.

LinkedIn: https://www.linkedin.com/in/gyuseok-kim-b12ab395/

Nanotechnology and Nanofabrication for Biological Applications

Abstract: Nanotechnologies exist around us. Cell phone, tablet, computer, watch and even in Oculus games. Due to the ever increasing need for smaller and faster devices, nanotechnology has been the subject of intense research and commercial activities. The traditional area of nanotechnology includes semiconductors and microelectromechanical system (MEMS) such as diode, transistor, solar cell, quantum dots, actuator and sensor. And most of the nanofabrication process requires lithography, deposition and etch techniques. Recently, non-traditional use of nanotechnology is emerging, especially in biology area. Gradient generator, droplet generator and cell culture device are examples of biological application. In this talk, I will present principle and examples of key nanofabrication techniques, and associated tool capabilities that Singh Center for Nanotechnology at the University of Pennsylvania provides. Then, I will introduce concepts and process flows of actual microfluidic devices to understand the nanofabrication for biological applications.

LRIG Philadelphia 3rd Virtual Scientific Meeting

posted Jan 6, 2021, 5:40 PM by Rodney Bednar   [ updated Jan 26, 2021, 11:34 AM ]

https://youtu.be/3BY4377JgPg


On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.





The 3rd Virtual Scientific Meeting is on Wednesday, January 20th, 2021 @ NOON!  

Please encourage your friends and colleagues to register now for this exciting talk.
REGISTER NOW!


The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) is proud to announce our next Virtual Scientific Meeting. This virtual forum provides an opportunity for Scientists to share their Research & Innovations with the entire LRIG Community.  This ongoing series is free to attend and open to all.

We are excited to hear from the GSK's Analytical Automation Specialist, Sharon Matamoros on Wednesday, January 20th at noon EST. 

Further details and required registration is on Eventbrite: https://www.eventbrite.com/e/lrig-philadelphia-virtual-scientific-meeting-jan-2021-tickets-129606810459


About this Event

Automated Platform Analytical Method to Determine Excipient Content in Biopharmaceutical Drug Product using Andrew Alliance Liquid Handler Robot

Overview of Presentation:

The Andrew Alliance liquid handler robot enables automated pipetting, flexible programmable settings, and simple drag and drop protocol designs. This talk describes the automation development challenges and solutions to fully automate a platform analytical method to determine excipient content in monoclonal antibody (mAb) biopharmaceutical drug product.

See below for Information on our speaker and an abstract of her presentation.


Sharon Matamoros

“Sharon Matamoros is an Analytical Automation Specialist in the small molecule High-Throughput Automation Group at the GSK Collegeville site. She has been a member of the team since 2018 and focuses on applying automation to accelerate early-phase drug development. She has a background in Analytical Chemistry”.

LinkedIn: https://www.linkedin.com/in/sharon-matamoros-0a600027/

Automated Platform Analytical Method to Determine Excipient Content in Biopharmaceutical Drug Product using Andrew Alliance Liquid Handler Robot

Sharon Matamoros, GlaxoSmithKline, 1250 South Collegeville Rd, Collegeville, PA 19426

Abstract : The implementation of laboratory automation can accelerate the chemistry, manufacturing, and control activities and build quality into the process. The Andrew Alliance liquid handler robot enables automated pipetting, flexible programmable settings, and simple drag and drop protocol designs. This liquid handler robot is user friendly and ideal for Scientists with limited robotics knowledge. This talk describes the automation development challenges and solutions to fully automate a platform analytical method to determine excipient content in monoclonal antibody (mAb) biopharmaceutical drug product. The automation accomplishes standard solution preparations for a calibration curve, samples with a variety of viscosities, and analytical controls. Analyst vs robot performance is discussed including linearity, precision and accuracy of the results. Automation was successfully implemented in a new laboratory to execute a robust sample preparation protocol.


LRIG Philadelphia 2nd Virtual Scientific Meeting

posted Sep 30, 2020, 12:45 PM by Rodney Bednar   [ updated Dec 6, 2020, 11:52 AM ]

https://www.youtube.com/watch?v=0J2m6RfwDxUOn-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.

Virtual WebEx @ Noon on Wednesday Dec 2nd 2020.

Register Now!   

The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) is proud to announce the continuation of Virtual Scientific Meetings. This virtual forum provides an opportunity for Scientists to share their Research & Innovations with the entire LRIG Community.  Free to attend, open to all.

We are excited to share LRIG Philadelphia's 2nd Virtual Scientific Meeting is at Noon on Wednesday Dec 2nd.  This lunchtime "WebEx"  event will feature a presentation by a scientists with the U.S. Food and Drug Administration (FDA) and an opportunity for questions and answers.

Further details and required registration is on Eventbritehttps://www.eventbrite.com/e/lrig-philadelphia-virtual-scientific-meeting-tickets-127498173469


Please help us get the word out about this new forum for Scientists to share their Research and Innovations with the entire LRIG community.   All Laboratory Research and Innovation Group of Philadelphia (LRIG-Philadelphia) events are free and open to all interested people.   Please reach out to your colleagues, friends and contacts who may be interested in attending or presenting in a future event.


About this Event

Applications of Biological Target-Based Assays for Chemical Detection.

Although biological target-based assays are commonly used in pharmacology and toxicology, these assays can also be used for chemical detection. In this presentation, the applications, advantages, and limitations of biological target assays for chemical detection will be discussed, and a specific application will be highlighted.  

 

See below for Information on our speakers and an abstract of their presentation.



Michael F. Santillo, Ph.D.


For the past decade I worked as a research scientist at the Center for Food Safety and Applied Nutrition (CFSAN) within the U.S. Food and Drug Administration (FDA). My research at FDA focuses on developing in vitro methods (cellular and biochemical assays) for detecting and predicting the safety of chemicals related to foods and dietary supplements. Additionally, I serve as a FDA’s representative on the assay evaluation team for Tox21, a consortium among several federal agencies who are employing high-throughput screening assays for toxicology testing. I am a member of the American Chemical Society and Society for Laboratory Automation and Screening (SLAS) and served on editorial boards for SLAS Technology and the Journal of Pharmacological and Toxicological Methods. Before joining FDA, I received a Ph.D. in chemistry from Penn State University, where I developed microfluidic devices for cellular assays.


LinkedIn: https://www.linkedin.com/in/mfsantillo


Abstract

Assays that measure interactions between chemicals and their biological targets (receptors, enzymes, ion channels, transporters) play important roles in pharmacological and toxicological research. However, biological target-based assays can also be employed as analytical techniques, where they serve as biosensors for detecting compounds (e.g., drugs, toxins, environmental pollutants) in complex sample matrices. This presentation will provide an overview of the advantages, challenges, and applications of biological target-based assays for chemical detection, especially ones that have been validated and recognized by regulatory agencies or standards organizations (e.g., AOAC International). In addition to providing an overview of these assays, a specific application will be highlighted, where a biological target assay was developed for detecting erectile dysfunction drugs and analogues in tainted products marketed as dietary supplements.



Invite your friends, colleagues, or potentially interested contacts.  Free Registration is Required. Register Here.

LRIG Philly Inaugural Virtual Scientific Meeting

posted Sep 30, 2020, 12:45 PM by Rodney Bednar   [ updated Nov 29, 2020, 10:28 AM ]

https://www.youtube.com/watch?v=V1TrWN0rFQw  On-Demand Viewing of Event Recording is available for a limited time on LRIG's YouTube Channel.

Virtual WebEx @ Noon on Wednesday Oct 7th 2020.

Register Now!   

The Laboratory Research & Innovation Group of Philadelphia (LRIG-Philadelphia) is proud to announce Virtual Scientific Meetings. This virtual forum provides an opportunity for Scientists to share their Research & Innovations with the entire LRIG Community.  Free to attend, open to all.

We are excited to share LRIG Philadelphia's Inaugural Virtual Scientific Meeting is at Noon on Wednesday Oct 7th.  This lunchtime "WebEx"  event will feature an integrated presentation by two GSK scientists and an opportunity for questions and answers.

Further details and required registration is on Eventbrite https://www.eventbrite.com/e/lrig-philadelphia-virtual-scientific-meeting-tickets-122593152419


Please help us get the word out about this new forum for Scientists to share their Research and Innovations with the entire LRIG community.   All Laboratory Research and Innovation Group of Philadelphia (LRIG-Philadelphia) events are free and open to all interested people.   Please reach out to your colleagues, friends and contacts who may be interested in attending or presenting in a future event.


About this Event

Automation Enabled High-Throughput Experimentation for Acceleration of Small Molecule Development

Utilization of laboratory automation can accelerate the chemistry, manufacturing, and control (CMC) activities in pharmaceutical research and development. Automation allows us to accelerate product development by designing, implementing and validating automation protocols that enable high throughput experiments focusing on the characterization of GSK therapeutic candidates.

 

See below for Information on our speakers and an abstract of their presentation.


Sofia Kochiashvili is a Senior Scientist in the small molecule high-throughput automation group at the GSK Collegeville site. She has been a member of the team since 2017 and focuses on applying automation to accelerate early-phase drug development. She has a background in Biology and Chemistry.”

LinkedIn: https://www.linkedin.com/in/sofio-kochiashvili-193a28102


James Thomas is an Investigator in the small molecule high-throughput automation group at the GSK Collegeville site. He has been a member of the team since 2018 and focuses on applying automation to accelerate early-phase drug development. He has a background in Biomedical Engineering and Materials Engineering.”

LinkedIn: https://www.linkedin.com/in/jtdrexel/


Automation Enabled High-Throughput Experimentation for Acceleration of Small Molecule Development

Sofia Kochiashvili and James Thomas; GlaxoSmithKline, 1250 South Collegeville Rd, Collegeville, PA 19426

Utilization of laboratory automation can accelerate the chemistry, manufacturing, and control (CMC) activities in pharmaceutical research and development. Our goal is to accelerate product development by designing, implementing and validating automation protocols that enable high throughput experiments focusing on the characterization of GSK therapeutic candidates. Our automated workflows include crystallization & polymorph screening, formulation development, stability assessment, forced degradation and kinetic solubility studies. The global small molecule automation capabilities include: multi-functional Unchained Labs robotic platforms, Mettler Quantos and Chemspeed solid dispensing platforms, Hamilton, CyBio and Andrew liquid handling systems. These robots enable us to automate sample preparation on a miniaturized scale through liquid and solid dispensing (with integrated balance) combined with heating, cooling, stirring, vortexing and more. The systems are easily programmable, enabling the scientist to customize each experimental design. The platforms interface with analytical instrumentation (eg. HPLC and pH electrodes) to automate data handling by pulling the data from an entire study into a single database. While small molecule automation lab supports workflows ranging from early discovery to phase III clinical trials, we focus on accelerating Pre-CS to FTIH, concomitantly cutting down FTE efforts, money and time. Automation is a growing space with expanding workflow capabilities and collaborations extending outside of the department. Small-molecule automation has supported various departments, completing over 20,000 experiments in 2019.


Invite your friends, colleagues, or potentially interested contacts.  Free Registration is Required. Register Here.

Philly's Annual Vendor Show Rescheduled to April 28, 2022

posted Mar 11, 2020, 11:59 AM by Rodney Bednar   [ updated Apr 15, 2021, 8:53 AM ]

Event Rescheduled for April 28, 2022 Save THAT Date.
Thursday October 29, 2020  (4:00 PM to 8:00 PM) 
Philly LRIG Annual Vendor Exhibition 



DoubleTree by Hilton Philadelphia-Valley Forge 
301 West Dekalb Pike, 
King of Prussia, PA 19406 

Google Map Directions
Vendor Exhibition:
  4:00 PM to 8:00 PM
Novel Technologies Presentations:  4:30 PM to 8:00 PM
Free Food: (4:00-7:00) & Dessert (6:00 to 8:00)
Prizes Sponsored by SLAS and LRIG Philly!

Philly's Annual Vendor Show October 2019

posted May 13, 2019, 7:21 AM by Rodney Bednar   [ updated Apr 11, 2020, 2:06 AM ]


Thursday October 17, 2019  (4:00 PM to 8:00 PM) 
Philly LRIG Annual Vendor Exhibition 


DoubleTree by Hilton Philadelphia-Valley Forge 
301 West Dekalb Pike, 
King of Prussia, PA 19406 

Google Map Directions


Vendor Exhibition:
  4:00 PM to 8:00 PM
Novel Technologies Presentations:  4:30 PM to 8:00 PM
Free Food: (4:00-7:00) & Dessert (6:00 to 8:00)
Prizes Sponsored by SLAS and LRIG Philly!

Overview:

Free food, prizes, networking, 42 vendors/exhibitors and great talks!

The LRIG Philadelphia Fall Vendor Exhibition is scheduled for Thursday October 17th 2019 and will be held at the DoubleTree by Hilton Philadelphia Valley Forge from 4:00pm to 8:00 pm. This Technology Exhibition will showcase the latest in laboratory instrumentation, automation, software, reagents and consumables. Free food will be served and the meeting will provide a wonderful networking opportunity for area scientists and engineers to connect and share ideas.

Last years event  was a huge success with plenty of superb free food, prizes, great talks, a high school robotics team demonstration.  Excellent Networking with 39 vendors and 292  registrants/attendees and plenty of old friends.   About ½ of our attendees were new members to Our Philly Chapter; bringing us up to over 1400 members in our LRIG Philadelphia Chapter! 

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